您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Bis-PEG8-acid
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Bis-PEG8-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis-PEG8-acid图片
CAS NO:1246189-43-4
包装与价格:
包装价格(元)
100mg电议
250mg电议

产品介绍
Bis-PEG8-acid 是一种 PROTAC linker,属于 PEG 类。Bis-PEG8-acid 可用于合成一系列 PROTAC 分子。Bis-PEG8-acid 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。
Cas No.1246189-43-4
分子式C20H38O12
分子量470.51
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bis-PEG8-acid is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.