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Aniline-MPB-amino-C3-PBD
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aniline-MPB-amino-C3-PBD图片
CAS NO:2412923-79-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Aniline-MPB-amino-C3-PBD,是一种由吡咯苯二氮卓 (PBD) 组成的细胞毒性药物。Aniline-MPB-amino-C3-PBD 是一种序列选择性DNA小沟结合剂。Aniline-MPB-amino-C3-PBD 作为 ADC 的有效载荷。具有抗微生物活性。
生物活性

Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selectiveDNAminor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

IC50& Target[1]

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strainE. coliK12 with potency of 2 pg/mL determined[1].

分子量

758.86

Formula

C42H46N8O6

CAS 号

2412923-79-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.