CAS NO: | 2412923-79-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selectiveDNAminor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1]. | |
IC50& Target[1] |
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体外研究 (In Vitro) | Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strainE. coliK12 with potency of 2 pg/mL determined[1]. | |
分子量 | 758.86 | |
Formula | C42H46N8O6 | |
CAS 号 | 2412923-79-4 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |