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Rebeccamycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rebeccamycin图片
CAS NO:93908-02-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Rebeccamycin,一种抗肿瘤抗生素,抑制 DNA 拓扑异构酶 I (DNA topoisomerase I)。Rebeccamycin 通过毒害拓扑异构酶 I 发挥其主要的抗肿瘤作用,对蛋白激酶 C 和拓扑异构酶 Ⅱ 的作用较小。
生物活性

Rebeccamycin, an antitumorantibiotic, inhibitsDNAtopoisomeraseI. Rebeccamycin appears to exert its primary antineoplastic effect by poisoningtopoisomeraseI and has negligible effect on protein kinase C andtopoisomeraseII[1][2].

IC50& Target[1]

Topoisomerase I

 

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Rebeccamycin is an antitumor antibiotic produced by the actinomyceteSaccharotrix aerocolonigeneswith activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma)[1].
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, includingStaphylococcus aureusandStreptococcus faecalis[3].

体内研究
(In Vivo)

Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia[2].

Animal Model:CDF1 mice (B16 melanoma, L1210 leukemia)[2]
Dosage:2, 4, 8, 16, 32, 64, 128, 256 mg/kg
Administration:I.p.; daily for 9 days
Result:Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.
分子量

570.38

Formula

C27H21Cl2N3O7

CAS 号

93908-02-2

结构分类
  • Antibiotics
  • Other Antibiotics
来源

the mycelium

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.