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Methotrexate monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methotrexate monohydrate图片
CAS NO:6745-93-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Amethopterin monohydrate
CL14377 monohydrate
WR19039 monohydrate
产品介绍
Methotrexate (Amethopterin) monohydrate 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate),可抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。Methotrexate monohydrate 也是一种免疫抑制剂和抗肿瘤剂,用于类风湿关节炎和研究多种癌症 (如急性淋巴细胞白血病)。
生物活性

Methotrexate (Amethopterin) monohydrate, anantimetaboliteandantifolateagent, inhibits the enzymedihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

IC50& Target

Traditional Cytotoxic Agents

 

体内研究
(In Vivo)

Methotrexate (Amethopterin) monohydrate reduces thymus and spleen indices of mice. Methotrexate monohydrate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate monohydrate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) monohydrate (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate monohydrate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4].

Clinical Trial
分子量

472.45

Formula

C20H24N8O6

CAS 号

6745-93-3

中文名称

甲氨蝶呤一水合物;氨甲蝶呤一水合物;氨甲叶酸一水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.