CAS NO: | 6745-93-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Methotrexate (Amethopterin) monohydrate, anantimetaboliteandantifolateagent, inhibits the enzymedihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3]. | |
IC50& Target |
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体内研究 (In Vivo) | Methotrexate (Amethopterin) monohydrate reduces thymus and spleen indices of mice. Methotrexate monohydrate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate monohydrate exposure on indices of thymus and spleens in mice[2]. | |
Clinical Trial | ||
分子量 | 472.45 | |
Formula | C20H24N8O6 | |
CAS 号 | 6745-93-3 | |
中文名称 | 甲氨蝶呤一水合物;氨甲蝶呤一水合物;氨甲叶酸一水合物 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |