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Mensacarcin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mensacarcin图片
CAS NO:808750-39-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Mensacarcin 是一种高度复杂的聚酮类化合物,在肿瘤细胞系中普遍具有强烈的抑制细胞生长的作用,并可能诱导黑色素瘤细胞的凋亡 (apoptosis)。Mensacarcin 靶向线粒体 (mitochondria),影响线粒体的能量代谢,激活 caspase 依赖的凋亡途径。Mensacarcin 是一种抗生素,也可作为抗体偶联药物 (ADCs) 的细胞毒性成分。
生物活性

Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally incancercell lines and potently inducesapoptosisin melanoma cells. Mensacarcin targets tomitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, anantibiotic, can be used as a cytotoxic component ofantibody-drug conjugates (ADCs)[1][2].

IC50& Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Mensacarcin (0-100 μM; 24 hours) exhibits general cytostatic but type-specific cytotoxic effects for melanoma cells[1].
Mensacarcin (2-50 μM; 15 hours) induces rapid apoptotic cell death in melanoma cells[1].
Mensacarcin exhibits potent cytostatic properties (mean of 50% growth inhibition=0.2 μM) in almost all cell lines of the National Cancer Institute (NCI)-60 cell line screen and relatively selective cytotoxicity against melanoma cells. Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwellingStreptomycesbacteria. Mensacarcin impairs mitochondrial function in melanoma cells[1].

Cell Viability Assay[1]

Cell Line:SK-Mel-28 and SK-Mel-5 melanoma cells, HCT-116 colon cancer cells
Concentration:0.01, 0.1, 1, 10, 100 μM
Incubation Time:24 hours
Result:Induced concentration- and time-dependent cell death in the two tested melanoma cell lines. HCT-116 colon carcinoma cells were strongly inhibited.

Western Blot Analysis[1]

Cell Line:SK-Mel-28, SK-Mel-5 cells
Concentration:2, 10, 50 μM
Incubation Time:15 hours
Result:Induced the formation of 89-kDa PARP-1 fragments as well as caspase-3 activation in SK-Mel-28 and SK-Mel-5 beginning between 6 and 15 h after exposure.
分子量

420.41

Formula

C21H24O9

CAS 号

808750-39-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.