Sandramycin

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Sandramycin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	100940-65-6
包装:	1mg
市场价:	8200元

产品名称

山卓霉素

产品介绍

Sandramycin 是一种从Nocardioides sp的培养液中分离出来的一种环状十肽抗菌素。Sandramycin 也可以有效地结合 DNA，并且是一种ADC的毒素分子。Sandramycin 对革兰氏阳性细菌 (Gram-positive bacteria) 具有活性，并具有有效的抗肿瘤活性。

生物活性

Sandramycin ia a cyclic depsipeptideantibioticisolated from cultured broth of aNocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is anADC cytotoxin. Sandramycin is active againstGram-positive bacteriaand has potent antitumor activity^[1]^[2]^[3].

IC₅₀& Target^[1]

Traditional Cytotoxic Agents

体外研究
(In Vitro)

Sandramycin has antimicrobial activity wtih MIC values of 0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL forBacillus subtilis(Rec⁺) A22508-2,B. subtilis(Rec^-) A22509-2-2,Staphylocccus aureus209P-A9497,S. aureus(echinomycin-resistant) A9628,Streptococcus faecalisA96 1 1,Escherichia coliA151 19 andE. coli(actinomycin-sensitive) A21780 (AS-19), respectively^[1].
Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC₅₀values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively^[2].

体内研究
(In Vivo)

Sandramycin (0.0125-1.6 mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice^[1].

Animal Model:	CDF1 female mice injected with leukemia P388 cells^[1]
Dosage:	0.0125 mg/kg, 0.025 mg/kg, 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg, 0.4 mg/kg, 0.8 mg/kg, 1.6 mg/kg
Administration:	Intraperitoneal injection; daily; for 5 days
Result:	Was moderately active in vivo against leukemia P388 in mice.

分子量

1221.32

Formula

C₆₀H₇₆N₁₂O₁₆

CAS 号

100940-65-6

中文名称

山卓霉素

结构分类

Antibiotics
Other Antibiotics

来源

Nocardioides sp.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.