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Licochalcone C
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Licochalcone C图片
CAS NO:144506-14-9
包装:20mg
市场价:1407元

产品介绍
Licochalcone C 可以抑制 α-葡萄糖苷酶，对 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B (PTP1B) 的 IC50 值分别为<100 nM 和 92.43 μM。
Cas No.144506-14-9
别名甘草查尔酮C
化学名(E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-enyl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
Canonical SMILESCC(=CCC1=C(C=CC(=C1OC)C=CC(=O)C2=CC=C(C=C2)O)O)C
分子式C21H22O4
分子量338.15
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Licochalcone C could inhibit α-glucosidase, with IC50s of<100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

Licochalcone C could inhibit α- glucosidase, with IC50s of<100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively[1]. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration-dependent manner. Licochalcone C treatment reduces the levels of the anti-apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells[2].

References:
[1]. Zhenghong Guo, et al. Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch). journal of functional foods 14 ( 2015 ) 324-336.
[2]. PENGLONG WANG, et al. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells. Mol Med Rep. 2015 Nov;12(5):7623-8.