CAS NO: | 518044-40-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | Maleimido-tri(ethylene glycol)-propionic acid is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1]. Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7[1].ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively[1].ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50of 195 and 202 nM, respectively[1].ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50of 286 and 274 nM, respectively[1]. | ||||||||||||||||
分子量 | 301.29 | ||||||||||||||||
性状 | Liquid | ||||||||||||||||
Formula | C13H19NO7 | ||||||||||||||||
CAS 号 | 518044-40-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(331.91 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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