NH2-PEG6-Boc is a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1]. NH2-PEG6-Boc is also anon-cleavable6 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

409.51

Liquid

C₁₉H₃₉NO₈

1286281-32-0

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)