Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

215.25

Liquid

C₁₀H₁₇NO₄

610791-05-4

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