Amino-PEG5-C2-acid is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. Amino-PEG5-C2-acid is anon-cleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

309.36

Oil

C₁₃H₂₇NO₇

1191078-74-6

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)