Azido-PEG6-alcohol is a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[1]. Azido-PEG6-alcohol is also anon-cleavable6 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

307.34

Liquid

C₁₂H₂₅N₃O₆

86770-69-6

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