Bis-PEG9-acid

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Bis-PEG9-acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1268488-70-5

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议
250mg	电议
500mg	电议
1 g	电议

产品介绍

Bis-PEG9-acid 是一种PROTAC linker，属于 PEG 类。Bis-PEG9-acid 可用于合成一系列 PROTAC 分子。Bis-PEG9-acid 是一种可降解 (cleavable) 的ADClinker，用于抗体偶联药物 (ADCs) 的合成。

生物活性

Bis-PEG9-acid is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. Bis-PEG9-acid is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

IC₅₀& Target^[1]

PEGs

Cleavable

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

514.56

性状

Solid

Formula

C₂₂H₄₂O₁₃

CAS 号

1268488-70-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month