Fmoc-NH-PEG6-CH2COOH is a cleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

561.62

Viscous liquid

C₂₉H₃₉NO₁₀

437655-96-4

Room temperature in continental US; may vary elsewhere.