CAS NO: | 528583-91-7 |
包装 | 价格(元) |
10μg | 电议 |
25μg | 电议 |
50μg | 电议 |
100μg | 电议 |
Cas No. | 528583-91-7 |
别名 | Aspirin-triggered Resolvin D1 |
化学名 | 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E19Z-docosahexaenoic acid |
Canonical SMILES | CC/C=C\C[C@@H](O)\C=C\C=C\C=C/C=C\[C@@H](O)C(O)C/C=C\CCC(=O)O |
分子式 | C22H32O5 |
分子量 | 376.5 |
溶解度 | 0.05mg/mL in PBS, pH 7.2 |
储存条件 | Store at -80℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).[3] 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.[3] In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. Analytical and biological comparisons of synthetic 17(R)-RvD1 with endogenously derived 17(R)-RvD1 have confirmed its identity as matching the natural product.[4] Reference: |