M-PEG10-Amine

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M-PEG10-Amine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1383658-09-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

m-PEG10-amine 是一种不可降解 (non-cleavable) 的含 10 个单元 PEG 的ADC linker，可用于合成抗体偶联药物 (ADC)。m-PEG10-amine 还是一种PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

生物活性

m-PEG10-amine is anon-cleavable10 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1]. m-PEG10-amine is also a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[1].

IC₅₀& Target^[1]

PEGs	Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

分子量

471.58

Formula

C₂₁H₄₅NO₁₀

CAS 号

1383658-09-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.