Azido-PEG5-acid

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Azido-PEG5-acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1425973-16-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Azido-PEG3-acid 是一种 PROTAC linker，属于 PEG 类。Mal-PEG1-acid 可用于合成 PROTAC 分子。比如合成CPT-APO (CPT: Camptothecin (HY-16560)) 偶联物。Azido-PEG3-acid 是一种不可降解 (non-cleavable) 的含 5 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

生物活性

Azido-PEG5-acid is a PEG-basedPROTAClinker can be used in the synthesis ofPROTACs, such as the conjugate CPT-APO (CPT: Camptothecin (HY-16560)). Azido-PEG5-acid is anon-cleavable5 unit PEGADClinker used in the synthesis ofantibody-drug conjugates (ADCs)^[1]^[2].

IC₅₀& Target

PEGs	Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

分子量

335.35

性状

Liquid

Formula

C₁₃H₂₅N₃O₇

CAS 号

1425973-16-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month