BI-6C9 是一种高度特异性的 BH3 相互作用域 (Bid) 抑制剂，可防止线粒体外膜电位 (MOMP) 和线粒体裂变，并保护细胞免受线粒体凋亡诱导因子 (AIF) 释放和神经元中不依赖半胱天冬酶的细胞死亡[ 1]。
| Cas No. | 791835-21-7 |
| 化学名 | N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-butanamide |
| Canonical SMILES | NC1=CC=C(SC2=CC=C(NC(CCCNS(C3=CC=C(OC)C=C3)(=O)=O)=O)C=C2)C=C1 |
| 分子式 | C23H25N3O4S2 |
| 分子量 | 471.6 |
| 溶解度 | 0.5mg/mL in ethanol, 30mg/mL in DMSO or in DMF |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a. |
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