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p,p'-DDD
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
p,p'-DDD图片
CAS NO:72-54-8
包装:250mg
市场价:514元

产品介绍
p,p'-DDD 是 p,p'-DDT 的主要代谢物。
Cas No.72-54-8
别名4,4-滴滴滴,4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane
Canonical SMILESClC1=CC=C(C(C(Cl)Cl)C2=CC=C(Cl)C=C2)C=C1
分子式C14H10Cl4
分子量320
溶解度Chloroform: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

p,p'-DDD is a metabolite of the organochlorine pesticide DDT. It is an agonist at estrogen receptor α (ERα) and ERβ, increasing transactivation with 20% relative effective concentrations (REC20) of 3.2 and 2.4 µM, respectively, in CHO-K1 cells expressing the human receptors. It inhibits DHT-induced androgen receptor transcription with a 20% relative inhibitory concentration (RIC20) of 0.71 µM. p,p'-DDD increases apoptosis in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 100 and 150 µg/ml. Blood levels of p,p'-DDD and the level of PBMC apoptosis are increased in children exposed to DDT compared with unexposed children. It is not considered lethal to hamsters (LD50 = ~5,000 mg/kg) but is to rats (LD50 = 3,750 mg/kg).