您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Evans blue
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Evans blue
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Evans blue图片
CAS NO:314-13-6
规格:≥98%
包装与价格:
包装价格(元)
2g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)960.81
FormulaC34H24N6O14S4.4Na
CAS No.314-13-6
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (104.1 mM)
Water: 100 mg/mL (104.1 mM)
Ethanol: <1 mg/mL
SMILES[O-]S(C1=CC(S([O-])(=O)=O)=C2C=CC(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(O)C6=C(N)C(S([O-])(=O)=O)=CC(S([O-])(=O)=O)=C6C=C5)C(C)=C4)C=C3C)=C(O)C2=C1N)(=O)=O.[Na+].[Na+].[Na+].[Na+]
SynonymsDirect Blue 53
实验参考方法
In Vitro

In vitro activity: Evans Blue is found to be inhibiting DNA binding of NF-κB at a low concentration of 100 μM. It has proven over the years to be a dependable stain for microscopic determination of cell death. Evans Blue is also a known blocker of a subset of a-amino-3-hydroxy-5-methyl-isoxazole/kainate receptors (IC50=355 nM) for the subunit combination GluR1,2. Evans blue is the first known δ-subunit-specific antagonist of ENaC and activates large-conductance Ca2+-activated K+ channels in sheep bladder myocytes and cultured endothelial cells of human umbilical veins.


Kinase Assay:


Cell Assay:

In VivoEvans blue pretreatment could inhibit the mast cells degranulation and that may be the main mechanism for prevent animals from C48/80-triggered anaphylaxis and systemic inflammation. Evans blue modulates the non-N-methyl-d-aspartate receptor in rat thalamic neurons, blocks the P2X-purinergic receptor in rat vas deferens, and inhibits the glutamate transporter in rat brain synaptic vesicles.
Animal modelCD hairless rats
Formulation & DosageDissolved in saline; 100 mg/kg; i.p.
References

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6123-7; J Pharmacol Exp Ther. 2005 Nov;315(2):965-9.