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iMAC2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
iMAC2图片
CAS NO:335166-36-4
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
iMAC2 是一种有效的 MAC 抑制剂,IC50 为 28 nM,LD50 为 15000 nM。
Cas No.335166-36-4
化学名3,6-dibromo-9-(2-fluoro-3-(piperazin-1-yl)propyl)-9H-carbazole
Canonical SMILESFC(CN1CCNCC1)CN2C3=C(C=C(Br)C=C3)C4=C2C=CC(Br)=C4
分子式C19H20Br2FN3.2HCl
分子量542.11
溶解度Limited solubility
储存条件Desiccate at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

iMAC2 is the inhibitor of mitochondrial apoptosis-induced channel (MAC) with the IC50 value of 28 nM[1]. MAC is a putative cytochrome c release channel involved in the intrinsic apoptotic pathway. MAC has been associated with oligomeric, not monomeric, Bax[2]. By blocking MAC and suppressing cytochrome c release, iMAC2 suppressed the onset of apoptotic markers [1].

In vitro: In cultured apoptotic FL5.12 cells, pre-treatment with iMAC2 resulted in a normal volume and residual Annexin V/PI staining. iMAC2 reduced apoptosis by more than 50%. Pre-treatment with iMAC2 induced a significant protection at low micromolar levels (IC50 = 2.5 μM). Pre-incubation with iMAC2 and iMAC3 essentially eliminated the release of cytochrome c (P< 0.0001) while nanomolar levels of iMAC2 completely blocked the current flow through MAC. iMAC2 inhibited release of cytochrome c by Bid-induced Bax activation with the IC50 values of 0.68 μM [1].

References:
[1] Peixoto PM1, Ryu SY, Bombrun A, Antonsson B, Kinnally KW.  MAC inhibitors suppress mitochondrial apoptosis.Biochem J. 2009 Oct 12;423(3):381-7.
[2] Dejean L M, Martinez-Caballero S, Guo L, et al.  Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel[J]. Molecular biology of the cell, 2005, 16(5): 2424-2432.