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Plumbagin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Plumbagin图片
CAS NO:481-42-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
25mg电议

产品介绍
Plumbagin (2-Methyljuglone) 是一种从 Plumbago zeylanica 中分离出来的萘醌,具有抗癌和抗增殖活性。
Cas No.481-42-5
别名白花丹素; 2-Methyljuglone
化学名5-hydroxy-2-methylnaphthalene-1,4-dione
Canonical SMILESCC1=CC(=O)C2=C(C1=O)C=CC=C2O
分子式C11H8O3
分子量188.18
溶解度≥ 6.35mg/mL in DMSO, ≥ 25.75 mg/mL in EtOH with ultrasonic
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 11.69 μM for A549 cells

Plumbagin, a quinonoid constituent isolated from the root of Plumbago zeylanica L., has been shown to exert anticarcinogenic, antiatherosclerotic, and antimicrobial effects.

In vitro: Plumbagin exhibited effective cell growth inhibition via inducing cancer cells to undergo G2/M phase arrest and apoptosis. Blockade of cell cycle was associated with increased levels of p21 and reduced amounts of Cdc2, Cdc25C and cyclinB1. Plumbagin treatment also found to enhance the levels of inactivated phosphorylated Cdc2 and Cdc25C. Blockade of p53 activity partially decreased plumbagin-induced apoptosis and G2/M arrest, indicating it might be operated by p53-dependent and independent pathway [1].

In vivo: To determine whether plumbagin inhibited the in vivo tumor growth, A549 cells were injected into nude mice. Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/day, where around 80% reductions in tumor size were observed, in contrast with mice treated with the vehicle. No sign of toxicity was observed in plumbagin-treated mice as judged by monitoring body weight [1].

Clinical trial: N/A

Reference:
[1] Hsu YL,Cho CY,Kuo PL,Huang YT,Lin CC.  Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J Pharmacol Exp Ther.2006 Aug;318(2):484-94.