CAS NO: | 418788-90-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
2,3-DCPE is a proapoptotic compound with selectivity for cancer cellsversusnormal human cells
Cas No. | 418788-90-6 |
化学名 | 2-((3-(2,3-dichlorophenoxy)propyl)amino)ethanol hydrochloride |
Canonical SMILES | ClC1=CC=CC(OCCCNCCO)=C1Cl.Cl |
分子式 | C11H15Cl2NO2.HCl |
分子量 | 300.61 |
溶解度 | 20 mg/ml in DMSO |
储存条件 | Desiccate at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | 2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells. It induces apoptosis in vitro in various cancer cell lines (IC50s = 0.89-2.69 μM) more effectively than in normal human fibroblasts (IC50 = 12.6 μM). 2,3-DCPE down-regulates Bcl-xL, however forced overexpression of Bcl-xL is sufficient to block 2,3-DCPE apoptosis induction.[1] 2,3-DCPE can induce S-phase arrest, upregulate p21, and activate ERK.[2] |