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Ivachtin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ivachtin图片
CAS NO:745046-84-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Ivachtin (Caspase-3 Inhibitor VII; Compound 7a) 是一种非肽、非竞争性和可逆的 caspase-3 抑制剂，IC50 为 23 nM。
Cas No.745046-84-8
别名Caspase-3 Inhibitor VII
化学名2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
Canonical SMILESCC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C
分子式C20H21N3O7S
分子量447.46
溶解度DMF: 2.5 mg/mL,DMF:PBS (pH7.2) (1:30): 0.03 mg/mL,DMSO: slightly soluble
储存条件Desiccate at 4℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ivachtin is a potent inhibitor of caspase-3 with IC50 value of 23 nM [1].

Caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. Sequential activation of caspases plays an important role in cell apoptosis.

Ivachtin is a potent and reversible inhibitor of caspase-3 in a noncompetitive way. Ivachtin was the most potent inhibitor against caspase-3, but the selectivity versus the remaining caspases was modest. In human Jurkat T cells treated with 10 μM staurosporin, Ivachtin protected cells in a higher level, which suggested that Ivachtin had a good cell permeability and antiapoptotic activity [1].

Reference:
[1]. Kravchenko DV, Kuzovkova YA, Kysil VM, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem, 2005, 48(11): 3680-3683.