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MA-0204
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MA-0204图片
CAS NO:2095128-17-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
MA-0204 是一种有效的、高选择性和可口服的过氧化物酶体增殖物激活受体 δ (PPARδ) 调节剂,对人类、小鼠和大鼠 PPARδ 的 EC50 分别为 0.4 nM、7.9 nM 和 10 nM。
Cas No.2095128-17-7
Canonical SMILESO=C(C[C@@H](CCCOC1=CC=CC=C1CN2C(C)=CN=C2C3=CC=C(C=C3)OC(F)(F)F)C)O
分子式C25H27F3N2O4
分子量476.49
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MA-0204 is a potent, highly selective PPARδ modulator with EC50s of 0.4, 7.9 and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD) [1].

MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. It has EC50s of 6,990 nM and more than 100,000 nM for human PPARα and PPARγ, respectively. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C[1].MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice[1].MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts[1].

PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle[1].

[1]. Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940.