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2-deoxy-D-Glucose-6-phosphate(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2-deoxy-D-Glucose-6-phosphate(sodium salt)图片
CAS NO:33068-19-8
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

A synthetic analog of glucose used in cell metabolism and cancer research

Cas No.33068-19-8
别名2-脱氧-D-葡萄糖-6-磷酸钠盐,2-Deoxyglucose-6-phosphate
化学名6-(dihydrogen phosphate) 2-deoxy-D-arabino-hexose, monosodium salt
Canonical SMILESO=CC[C@@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O.[Na+]
分子式C6H12O8P o Na
分子量266.1
溶解度10 mg/ml in PBS (pH 7.2)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-deoxy-D-Glucose is a synthetic analog of glucose used in cell metabolism and cancer research.[1] 2-deoxy-D-Glucose-6-phosphate (2-DG6P) is a derivative of 2-DG. It is produced in mammalian cells by the action of hexokinase on 2-DG. The accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.[2] However, the uptake of 2-DG by cells can be monitored in assays by the accumulation of 2-DG6P, which can be oxidized in vitro by glucose 6-phosphate dehydrogenase and reduce NADP+. In bacteria and yeast, 2-DG6P is metabolized to 2-DG by 2-DG6P phosphatase.

Reference
[1]. Kang, H.T., and Hwang, E.S. 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic Life Sciences 78(12), 1392-1399 (2006).
[2]. Urakami, K., Zangiacomi, V., Yamaguchi, K., et al. Impact of 2-deoxy-D-glucose on the target metabolite profile of a human endometrial cancer cell line Biomed.Res. 34(5), 221-229 (2013)