DBCO-NHCO-PEG4-amine

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1255942-08-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

DBCO-NHCO-PEG4-amine 是一种PROTAC连接桥，属于 PEG 类。DBCO-NHCO-PEG4-amine 是一种可降解 (cleavable) 的 ADC linker，可用于连接 MMAE (HY-15162) 和抗体 (例如 DBCO-VCpAB–MMAE 和 DBCO-TRX–MMAE，对 SKBR3 细胞的 EC50 分别为 280 nM 和 22 nM)。

生物活性

DBCO-NHCO-PEG4-amine is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. DBCO-NHCO-PEG4-amine is acleavableADC linkerused to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB–MMAE and DBCO-TRX–MMAE with EC₅₀s of 280 nM and 22 nM in SKBR3 cells, respectively)^[1].

IC₅₀& Target^[1]

Cleavable

PEGs

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

523.62

Formula

C₂₉H₃₇N₃O₆

CAS 号

1255942-08-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.