您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Azido-PEG3-Val-Cit-PAB-PNP
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Azido-PEG3-Val-Cit-PAB-PNP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azido-PEG3-Val-Cit-PAB-PNP图片
CAS NO:2055047-18-0
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Azido-PEG3-Val-Cit-PAB-PNP 是一种可降解 (cleavable) 的含 3 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。Azido-PEG3-Val-Cit-PAB-PNP 还是一种PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。
生物活性

Azido-PEG3-Val-Cit-PAB-PNP is acleavable3 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs[2].

IC50& Target[1][2]

PEGs

 

Protease Cleavable

 

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

分子量

773.79

Formula

C34H47N9O12

CAS 号

2055047-18-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.