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ICA(N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ICA(N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)图片
CAS NO:3374-88-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) 是具有抗寄生虫活性的 SK 通道抑制剂，IC50 为 2.1 μM.
Cas No.3374-88-7
别名N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine
Canonical SMILESC1(NC2=NC(C3=NC=CC=C3)=CS2)=NC=CC=C1
分子式C13H10N4S
分子量254.31
溶解度DMSO : ≥ 49.5 mg/mL (194.64 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].

[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. [2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76.