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TC-G 1006
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TC-G 1006图片
CAS NO:1324003-64-6
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
S1P1 Agonist III 是一种有效且具有口服活性的 S1P1 激动剂，EC50 为 18 nM； S1P3 上没有活动。
Cas No.1324003-64-6
化学名(Z)-N-((Z)-hydroxy((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)imino)methyl)-4-methoxynicotinimidic acid
Canonical SMILESCOC1=CC=NC=C1/C(O)=N/C(O)=N/C2=CC(C(F)(F)F)=C(C3=CC=CC=C3)C=C2
分子式C21H16F3N3O3
分子量415.37
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.IC50 value: 18 nM(EC50) [1]Target: S1P1 agonistWhen dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22 achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22 was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).

References:
[1]. Harrington PE, et al. Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett. 2011 Nov 23;3(1):74-8.