Sorafenib-13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally activeRafinhibitor withIC₅₀s of 6 nM and 20 nM forRaf-1andB-Raf, respectively. Sorafenib is a multikinase inhibitor withIC₅₀s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM forVEGFR2,VEGFR3,PDGFRβ,FLT3andc-Kit, respectively. Sorafenib inducesautophagyandapoptosis. Sorafenib has anti-tumor activity. Sorafenib is aferroptosisactivator^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

468.84

C₂₀¹³CH₁₃D₃ClF₃N₄O₃

1210608-86-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.