您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Apoptotic agent-2
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Apoptotic agent-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Apoptotic agent-2图片
CAS NO:2482310-18-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Apoptotic agent-2 (compound 14b) 通过下调 Bcl-2 和上调 Bax 和 caspase-3 诱导细胞凋亡 (apoptosis)。Apoptotic agent-2 具有抗增殖活性,可用于癌症研究。
生物活性

Apoptotic agent-2 (compound 14b) inducesapoptosisby down-regulation ofBcl-2and up-regulation ofBaxand caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used forcancerresearch[1].

IC50& Target[1]

Bax

 

Caspase 3

 

Bcl-2

 

体外研究
(In Vitro)

Apoptotic agent-2 (compound 14b) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2, MCF-7 and WI-38 (normal human cells) cells with IC50values of 1.96, 1.12, 2.38 and 107.5 μM, respectively[1].
Apoptotic agent-2 (compound 14b) (1.12 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 10.92 folds and 9.7 folds, respectively, and decreases the level of Bcl-2 by 3.3 folds[1].

Cell Cycle Analysis[1]

Cell Line:HepG-2 cells
Concentration:1.12 μM
Incubation Time:24 hours
Result:The percentage of cells in the G2-M phase increased while the percentage of cells in G0-G1 phase and S phase decreased.

Apoptosis Analysis[1]

Cell Line:HepG-2 cells
Concentration:1.12 μM
Incubation Time:24 hours
Result:Increased the early apoptosis ratio from 0.69% to 5.17% and increased the late apoptosis ratio from 0.32% to 12.11%.
分子量

481.96

Formula

C25H16ClN7S

CAS 号

2482310-18-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.