BBR-BODIPY 是一种荧光探针 (fluorescent probe)，可以筛选其与靶细胞的相互作用。BBR-BODIPY 诱导细胞凋亡改变凋亡相关蛋白的表达。
| 生物活性 | BBR-BODIPY is afluorescent probethat allows screening its interaction with the targeted cells. BBR-BODIPY inducesapoptosisand changes the expression of apoptosis-related proteins[1]. |
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体外研究
(In Vitro) | BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) has anti-proliferative activity[1].
BBR-BODIPY (2-16 μM; 5-60 mins; MCF7 cells) could be quickly taken up into MCF7 cells in 5 mins and the fluorescence intensity exhibits a time-dependent manner[1].
BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) accumulates in mitochondria and overlaps with Mito tracker red to display yellow fluorescence with a Pearsons co-localization coefficient of 0.72[1].
BBR-BODIPY (8 μM, 12 hours) induces apoptosis in MCF7 cells through a mitochondrial pathway[1].
Cell Cytotoxicity Assay[1] | Cell Line: | MCF7 and MDA-MB-231 cells | | Concentration: | 1 , 2 , 4 , 8 , 16 and 32 μM | | Incubation Time: | 24 hours | | Result: | Inhibited withIC50values of 40.81 and 41.46 μM for MCF7 and MDA-MB-231 cells, respectively. |
Western Blot Analysis[1] | Cell Line: | MCF7 cells | | Concentration: | 8 μM | | Incubation Time: | 12 hours | | Result: | The amounts of Bax and Cyto C released from mitochondria and cleaved Caspase 9 were up-regulated in MCF7 cells. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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