Anticancer agent 65 (compound 4c) shows excellent activity incancercell lines, especially A549 cells, with anIC₅₀of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causesapoptosis, ROS generation and collapse ofMMPin A549 cells^[1].

Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2^[1].

589.89

C₃₆H₆₃NO₅

2407861-48-5

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