PROTAC Bcl-xL degrader-2

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	5mg
市场价:	14500元

产品介绍

PROTAC Bcl-xL degrader-2 是一种基于von Hippel-Lindau配体的Bcl-xL(Bcl-2家族成员) 降解剂，IC₅₀为 0.6 nM。

生物活性

PROTACBcl-xL degrader-2 is a potentBcl-xL(Bcl-2family member) degrader based onvon Hippel-Lindauligand, with anIC₅₀of 0.6 nM.

IC₅₀& Target^[1]

Bcl-xL

0.6 nM (IC₅₀)

VHL

体外研究
(In Vitro)

PROTAC Bcl-xL degrader-2 (PROTAC 6; 0.1 nM-10 μM; 24 hours) treatment decreases the level of Bcl-xL protein in THP-1 cells^[1].
PROTAC Bcl-xL degrader-2 (PROTAC 6) inhibits caspase 3/7 activity in MOLT-4 cells with an IC₅₀of 466 nM^[1].

Western Blot Analysis^[1]

Cell Line:	THP-1 cells
Concentration:	0.1 nM-10 μM
Incubation Time:	24 hours
Result:	Led to monotonic decreases in observed Bcl-xL protein.

分子量

1329.60

Formula

C₆₈H₈₀N₈O₁₄S₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.