PROTACBcl-xL degrader-1 is aPROTACthat comprises aBcl-xL(Bcl-2family member) ligand binding group, a linker and anIAPE3 ligasesbinding group.PROTACBcl-xL degrader-1 is a potentBcl-xLdegrader, and shows toxicity for human platelets and MyLa 1929 cells withIC₅₀values of 62 nM and 8.5 μM, respectively^[1].

PROTAC Bcl-xL degrader-1 (Compound 8a; 0.01-3 μM; 16 hours; MyLa 1929 cells) treatment potently and dose-dependently induces BCL-XL degradation in MyLa 1929 cells^[1].
PROTAC Bcl-xL degrader-1 (Compound 8a) is able to induce remarkable BCL-XL degradation in a dose-dependent manner across all tested cell lines (A549, MDA-MB-231, SW620, MeWo, SK-MEL28, and CHL-1 cell lines), suggesting the broad application across cancer types^[1].

1514.28

C₇₆H₉₆ClF₃N₁₀O₁₁S₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.