Mcl1-IN-9

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Mcl1-IN-9

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1810769-31-3

包装与价格：

产品介绍

Mcl1-IN-9 是一种有效的髓细胞白血病基因 1(Mcl-1)抑制剂，在重组的 BCR-ABL+ B-ALL 细胞中的IC₅₀值为 446 nM，K_i值为 0.03 nM。

生物活性

Mcl1-IN-9 is a potentmyeloid cell leukemia-1 (Mcl-1)Inhibitor with anIC₅₀of 446 nM in reengineered BCR-ABL+ B-ALL cells and aK_iof 0.03 nM^[1].

IC₅₀& Target^[1]

Mcl-1

0.03 nM (Ki)

体外研究
(In Vitro)

Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range^[1].

体内研究
(In Vivo)

Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses^[1].

分子量

639.18

Formula

C₃₇H₃₉ClN₄O₄

CAS 号

1810769-31-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.