BRD4 Inhibitor-15

立即咨询

BRD4 Inhibitor-15

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2761366-60-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

BRD4 Inhibitor-15 (compound 13) 是一种有效的BRD4抑制剂，IC₅₀为 18 nM。 BRD4 Inhibitor-15 通过调节Bcl-2/Bax蛋白，激活caspase-3信号通路，诱导 22RV1 细胞凋亡（apoptosis）。 BRD4 Inhibitor-15 下调 22RV1 细胞中c-Myc水平。 BRD4 Inhibitor-15 可用于前列腺癌研究。

生物活性

BRD4Inhibitor-15 (compound 13) is a potentBRD4inhibitor, with anIC₅₀of 18 nM.BRD4Inhibitor-15 inducesapoptosisof 22RV1 cells by regulatingBcl-2/Baxproteins and activatingcaspase-3signaling pathway.BRD4Inhibitor-15 down-regulates thec-Myclevel in 22RV1 cells.BRD4Inhibitor-15 can be used for prostatecancerresearch^[1].

IC₅₀& Target

BRD4(1)

18 ± 1.1 nM (IC₅₀)

Bcl-2

Bax

Caspase-3

Procaspase-3

体外研究
(In Vitro)

BRD4 Inhibitor-15 (compound 13) shows potent anti-proliferative activity against enzalutamide-resistant 22RV1 cells and LNCap cells, with IC₅₀values of 8.27 ± 0.28 and 7.33 ± 0.49 μM, respectively^[1].

分子量

359.42

Formula

C₂₂H₂₁N₃O₂

CAS 号

2761366-60-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.