Anticancer agent 64

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Anticancer agent 64

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Anticancer agent 64 (化合物 5m) 对 CCRF-CEM 细胞具有细胞毒性，其IC₅₀为2.4 μM。Anticancer agent 64 通过诱导细胞凋亡表现出良好的抗癌活性。Anticancer agent 64 诱导 caspase 3 和 7 的激活和 PARP 的裂解。Anticancer agent 64 具有明显的线粒体去极化作用。

生物活性

Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, withIC₅₀of 2.4 μM. Anticancer agent 64 shows good anticancer activity throughapoptosisinduction. Anticancer agent 64 inducescaspase 3and 7 activation andPARPcleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization^[1].

IC₅₀& Target

Caspase 3

Caspase-7

Bcl-2

Bax

PARP

体外研究
(In Vitro)

Anticancer agent 64 (compound 5m) increases BAX expression and decreases Bcl-2 protein expression^[1].
. Anticancer agent 64 shows significant increasement in cells accumulation in the G2/M phase of the cell cycle, while proportion of cells in S phase is reduced^[1].

分子量

510.77

Formula

C₃₁H₄₆N₂O₂S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.