Ac-DEVD-CMK

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Ac-DEVD-CMK

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

285570-60-7

包装与价格：

产品名称

Caspase-3 Inhibitor III

产品介绍

Ac-DEVD-CMK (Caspase-3 Inhibitor III) 是一种选择性且不可逆的caspase-3抑制剂。Ac-DEVD-CMK 显着抑制由高水平葡萄糖或3,20-dibenzoate (IDB; HY-137295) 诱导的凋亡。Ac-DEVD-CMK 可以用于多种实验方法以抑制细胞凋亡。

生物活性

Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversiblecaspase-3inhibitor. Ac-DEVD-CMK significantly inhibitsapoptosisinduced by high levels of glucose or3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibitapoptosis^[1]^[2]^[3].

IC₅₀& Target^[1]^[2]

Caspase-3

体外研究
(In Vitro)

Ac-DEVD-CMK (100 μM; 24 小时) 抑制 IDB 诱导的细胞凋亡^[3]。

Apoptosis Analysis^[3]

Cell Line:	Jurkat cells
Concentration:	100 μM
Incubation Time:	24 h
Result:	Inhibited ingenol IDB (10 μM)-induced apoptosis.

体内研究
(In Vivo)

Ac-DEVD-CMK (Caspase-3 Inhibitor III; 25 mg/kg; 腹腔给药; 单剂量; APAP 后 3 小时) 显着减弱对乙酰氨基酚 (APAP; HY-66005) 诱导的肝损伤 (AILI)^[4]。

Animal Model:	6- to 8-week-old females and males Sdc1^-/- mice^[4]
Dosage:	25 mg/kg
Administration:	IP; single dose; 3 hours post-APAP
Result:	Significantly attenuated APAP (ip; 500 or 625 mg/kg)-induced liver injury (AILI), indicating that inhibition of GSK-3β or caspase-3 activity mitigates liver damage.

分子量

550.94

Formula

C₂₁H₃₁ClN₄O₁₁

CAS 号

285570-60-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.