您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Dynorphin A TFA
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Dynorphin A TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
强啡肽A 三氟乙酸
产品介绍
Dynorphin A TFA 是一种内源性阿片肽,参与中枢神经系统 (CNS) 的抑制性神经传递。Dynorphin A TFA 是一种高效的 kappa 阿片受体 (KOR) 激动剂,也是其他阿片受体的激动剂,如 mu (MOR) 和 delta (DOR)。Dynorphin A TFA 可诱导神经元死亡,可用于神经系统疾病的相关研究。
生物活性

Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potentkappaopioid receptor(KOR)agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research ofneurological disease[1][2].

IC50& Target[3]

Human Endogenous Metabolite

 

Caspase-3

 

κ Opioid Receptor/KOR

 

体外研究
(In Vitro)

Dynorphin A TFA (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death[3].
dynorphin A TFA (33 μM, 4 h) elevates [Ca2+]iand causes a significant loss of neurons[4].
dynorphin A TFA (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe[5].

Cell Viability Assay[3]

Cell Line:Mouse striatal neurons
Concentration:10 μM
Incubation Time:0, 24, 48, 72 h
Result:Induced neuronal death (identified by the fragmentation and destruction of the cell body and neurites).
体内研究
(In Vivo)

Dynorphin A TFA (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats[5].
Dynorphin A TFA (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain[6].

Animal Model:24 h water-deprived male rats[5]
Dosage:1 μg of 2 μL
Administration:Intracerebroventricular injection
Result:Inhibited vasopressin (VP) release 30 min upon injection.
Animal Model:Male ddY mice[6]
Dosage:15, 150, 1500 pmol/5 μL per day for 4 days
Administration:Intracerebroventricular injection
Result:Attenuated the repeated stress-induced escape failures from the shock.
分子量

2261.50

Formula

C101H156F3N31O25

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln

Sequence Shortening

YGGFLRRIRPKLKWDNQ

中文名称

强啡肽A 三氟乙酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.