Rosiglitazone-d3 (BRL 49653-d3) is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally activePPARγagonist withEC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, andPPARγ, respectively. Rosiglitazone binds toPPARγwith aK_dof approximately 40 nM. Rosiglitazone is also an activator ofTRPC5(EC₅₀=~30 μM) and an inhibitor ofTRPM3^[1][2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

360.45

C₁₈H₁₆D₃N₃O₃S

1132641-22-5

罗格列酮 d3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.