CAS NO: | 867324-12-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | LBW242, a 3-mer and Smac mimetic, is a potent and orally active proapoptoticIAPinhibitor. LBW242 shows effects on mutant FLT3-expressing cells. LBW242 has activity against multiple myeloma, and potentiates TRAIL- and anticancer drug-mediated cell death of ovariancancercells[1][2]. | ||||||||
体外研究 (In Vitro) | LBW242 is a 3-mer and Smac mimetic, based on the ability of the NH2-terminal seven amino acids of Smac to neutralize the BIR3 domain of X-chromosome-linked IAP (XIAP). LBW242 partially inhibits the growth of mutant FLT3-expressing lines, MV4;11 at 1 μM[1]. Cell Viability Assay[1]
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体内研究 (In Vivo) | LBW242 (50 mg/kg; p.o.; daily for 10 days) reduces tumor burden[1].
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分子量 | 454.65 | ||||||||
Formula | C27H42N4O2 | ||||||||
CAS 号 | 867324-12-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |