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KU 0060648
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KU 0060648图片
CAS NO:881375-00-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品名称
KU0060648, KU-0060648
产品介绍

生物活性

KU0060648是一种有效且选择性的DNA依赖性蛋白激酶(DNA-PK)抑制剂(IC50 = 8.6 nM);对DNA-PK的选择性是其他PIKK的20-1000倍,并且有60种激酶。KU-0060648可提高HDR效率并衰减NHEJ频率。

化学数据

目录号A13224
作用机制Inhibitor (抑制剂)
M. Wt692.1
FormulaC33H34N4O4S.3HCl
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.881375-00-4
SynonymsKU0060648, KU-0060648
SMILESCCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7

溶解度

In vitro (25°C)DMSO0.39 mg/mL (0.66 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% propylene glycol, 5% Tween 80, 65% D5W19 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM14.45 mL72.24 mL144.49 mL
0.5 mM2.89 mL14.45 mL28.9 mL
1 mM1.44 mL7.22 mL14.45 mL
5 mM0.29 mL1.44 mL2.89 mL

*The above data is based on the productmolecular weight 692.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.