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SB-3CT
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB-3CT图片
CAS NO:292605-14-2
规格:≥98%
包装与价格:
包装价格(元)
1mg电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)306.40
FormulaC15H14O3S2
CAS No.292605-14-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 61 mg/mL (199.1 mM)
Water:<1 mg/mL
Ethanol: 10 mg/mL (32.6 mM)
Solubility (In vivo)4% DMSO+corn oil: 10 mg/mL
SynonymsSB3CT; SB3-CT; SB-3CT;

Chemical Name: 2-(((4-phenoxyphenyl)sulfonyl)methyl)thiirane

InChi Key: LSONWRHLFZYHIN-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2

SMILES Code: O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O

实验参考方法
In Vitro

In vitro activity: SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro.


Cell Assay: PC3 cells are seeded in 35-mm dishes (5×104 cells/dish) in complete culture medium. The next day, the medium is replaced with complete medium supplemented with 1% DMSO alone (vehicle) or SB-3CT (final concentrations 0.1-50 μM) in 1% DMSO. At various times, the cells are harvested with trypsin and counted.

In VivoIn L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion.
Animal modelMouse L-CI.5s T-cell lymphoma model
Formulation & DosageDissolved in 10% DMSO.; 50 mg/kg; i.p. injection
ReferencesCancer Res. 2005 May 1;65(9):3523-6; Int J Cancer. 2006 Jun 1;118(11):2721-6.