CAS NO: | 292605-14-2 |
规格: | ≥98% |
包装 | 价格(元) |
1mg | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Molecular Weight (MW) | 306.40 |
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Formula | C15H14O3S2 |
CAS No. | 292605-14-2 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 61 mg/mL (199.1 mM) |
Water:<1 mg/mL | |
Ethanol: 10 mg/mL (32.6 mM) | |
Solubility (In vivo) | 4% DMSO+corn oil: 10 mg/mL |
Synonyms | SB3CT; SB3-CT; SB-3CT; Chemical Name: 2-(((4-phenoxyphenyl)sulfonyl)methyl)thiirane InChi Key: LSONWRHLFZYHIN-UHFFFAOYSA-N InChi Code: InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2 SMILES Code: O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O |
In Vitro | In vitro activity: SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro. Cell Assay: PC3 cells are seeded in 35-mm dishes (5×104 cells/dish) in complete culture medium. The next day, the medium is replaced with complete medium supplemented with 1% DMSO alone (vehicle) or SB-3CT (final concentrations 0.1-50 μM) in 1% DMSO. At various times, the cells are harvested with trypsin and counted. |
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In Vivo | In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion. |
Animal model | Mouse L-CI.5s T-cell lymphoma model |
Formulation & Dosage | Dissolved in 10% DMSO.; 50 mg/kg; i.p. injection |
References | Cancer Res. 2005 May 1;65(9):3523-6; Int J Cancer. 2006 Jun 1;118(11):2721-6. |