Paraherquamide A (PNU-97333) 是一种有毒代谢物，可从 Penicillium paraherquei 中分离出来。
| Cas No. | 77392-58-6 |
| 别名 | 对郝喹酰胺A,PNU-97333 |
| Canonical SMILES | CC(C=CO1)(C)OC2=C1C(NC([C@]34C[C@](CN(CC[C@]5(O)C)[C@]5(C6=O)C7)(N6C)[C@]7([H])C3(C)C)=O)=C4C=C2 |
| 分子式 | C28H35N3O5 |
| 分子量 | 493.6 |
| 溶解度 | DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 µg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg). |
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