CAS NO: | 213819-48-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Belotecan hydrochloride (CKD-602 hydrochloride), aTopoisomeraseIinhibitor, is a synthetic camptothecin derivative. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells[1]. Belotecan shows a significant anticancer effect on glioma cells, with IC50values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG[2]. | ||||||||||||||||
体内研究 (In Vivo) | Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 469.96 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H28ClN3O4 | ||||||||||||||||
CAS 号 | 213819-48-8 | ||||||||||||||||
中文名称 | 盐酸贝洛替康 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 12.5 mg/mL(26.60 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |