CAS NO: | 534605-78-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibitsDNAtopoisomeraseIwith anIC50of 2.3 μM. CH-0793076 is efficacious against cells expressingBCRP(breastcancerresistance protein)[1]. | |
IC50& Target[1] |
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体外研究 (In Vitro) | CH0793076 (TP3076) (6 days at 37℃) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC50s of 0.35 and 0.18 nM, respectively[1]. | |
体内研究 (In Vivo) | TP300 (1-100 mg/kg; bolus intravenous injection once per week for 3 weeks, for a total of three doses), a water-soluble prodrug of CH0793076, shows more than 50% of tumor growth inhibition in all nine models, regardless of the expression of BCRP (WiDr, HT-29, NCI-H460 and AsPC-1, HCT116, COLO 201, HCT-15, Calu-6 and NCI-N87)[1]. | |
分子量 | 458.51 | |
Formula | C26H26N4O4 | |
CAS 号 | 534605-78-2 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |