MDM2-p53-IN-15 是MDM2-p53的抑制剂，其IC50值为 26.1 nM。MDM2-p53-IN-15 抑制多种癌细胞的增值并诱导细胞凋亡。MDM2-p53-IN-15 可用于癌症的研究。
| 生物活性 | MDM2-p53-IN-15 is aMDM2-p53inhibitor with anIC50value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of variouscancercells and induces cellapoptosis. MDM2-p53-IN-15 can be used for the research ofcancer[1]. |
| IC50& Target | IC50: 26.1 nM (MDM2-p53)[1] |
体外研究
(In Vitro) | MDM2-p53-IN-15 (1–100 μM; 48 h) inhibits HCT116 cells proliferation[1].MDM2-p53-IN-15 (10-20 μM; 72-96 h) affects SJSA-1, LNCaP and MCF-7 proliferation[1].MDM2-p53-IN-15 (10-15 μM; 96 h) affects cell death and apoptosis in SJSA1 cells[1].MDM2-p53-IN-15 (0-1 μM; 1 h 30 min) dissociates MDM2-p53 complexes[1].
Cell Proliferation Assay[1] | Cell Line: | HCT116 cells | | Concentration: | 1-100 μM | | Incubation Time: | 48 hours | | Result: | Showed antiproliferative activity to HCT116 cells with an IC50value of 18.8 μM. |
Cell Proliferation Assay[1] | Cell Line: | SJSA-1, LNCaP and MCF-7 cell lines | | Concentration: | 10-20 μM | | Incubation Time: | 72 and 96 hours | | Result: | Inhibited SJSA-1, LNCaP and MCF-7 cells proliferation with IC50values of 10.7, 11.4 and 9.7 μM, respectively. |
Apoptosis Analysis[1] | Cell Line: | SJSA-1 cells | | Concentration: | 10-15 μM | | Incubation Time: | 96 hours | | Result: | Approximately 1.3-fold increased LDH releases at a concentration of 15 μM approximately 1.3-fold increased and induced SJSA-1 cells death with loss of volume. Induced accumulation of cells in G0/G1 phase while decreased the percentage of cells in both S and G2/M phases, thus affects cell cycle. |
Cell Viability Assay[1] | Cell Line: | U87MG and SHSY-5Y cells | | Concentration: | 0-1 μM | | Incubation Time: | 1 h 30 min | | Result: | Selectively inhibited MDM2-p53 PPIs with an IC50value of 26.1 nM, while inhibited MDM4-p53 PPIs with a lower potency with an IC50value of 219 nM. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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