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Anticancer agent 50
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anticancer agent 50图片
CAS NO:2487457-15-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Anticancer agent 50 (compound 6) 是一种有效的 ABCB1 外排泵调节剂。Anticancer agent 50 显示细胞毒作用和抗增殖作用。Anticancer agent 50 降低细胞周期蛋白 D1 的表达并诱导 p53 表达。Anticancer agent 50 具有研究T淋巴瘤的潜力。
生物活性

Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma[1].

体外研究
(In Vitro)

Anticancer agent 50 (compound 6) (0-100 μM) shows cytotoxic effects with IC50s of 0.67, 0.90 μM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively[1].
Anticancer agent 50 (0-100 μM) shows antiproliferative effects with IC50s of 3.84, 1.34 μM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively[1].
Anticancer agent 50 (0.1, 0.5, 2 μM; 24 h) inhibits cell cycle progression through the reduction of the expression of cyclin D1 and inhibits cell proliferation by inducing p53 expression[1].
Anticancer agent 50 (0.1, 0.5, 2, 10 μM; 72 h) inhibits cell growth by 12% in SH-SY5Y cells[1].

RT-PCR[1]

Cell Line:JURKAT cells
Concentration:0.1, 0.5, 2 μM
Incubation Time:24 h
Result:Significantly reduced cyclin D1 expression and increased the level of p53.
分子量

563.55

Formula

C30H32N2O4Se

CAS 号

2487457-15-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.